research scientist
Responsibility
- apply cellular and molecular techniques to assay cell biology pathways in iPSC-derived neurons from patients
- study the mechanisms of action of autophagy modulators of the endolysosomal pathway in cellular models of neurodegenerative disease
- conduct focussed compound evaluation for correction of disease phenotypes in endolysosomal biology
Show more +11 - undertake maintenance culture and differentiation of iPSC lines into neuronal populations such dopaminergic neurons and motor neurons
- generate robust and reproducible experimental data by following best lab practices and guidelines
- maintain accurate records of experiments and data
- contribute to wider project planning, including ideas for new research projects
- determine the most appropriate methodologies to test hypotheses and identify suitable alternatives if technical problems arise
- select, follow, and adapt experimental protocols·
- gather, analyse, and present scientific data from a variety of sources
- contribute to internal scientific reports and the presentation of data/papers as required; and regularly contribute to lab team meetings
- manage own research and administrative activities, within guidelines provided by senior colleagues
- undertake translational research projects
- undertake analysis of experimental results and interpretation
Requirements
- hold a PhD / DPhil in molecular or cellular biology
- extensive experience in cell culture, preferentially in stem cell -derived models of neurological disorders
- skilled with performing cellular assays such as high-content imaging, electrophysiology, multi-electrode arrays, calcium imaging
Show more +7 - skilled in molecular biology techniques
- good track record of peer-reviewed publications
- skilled with analysis and interpretation of research data
- able to work independently to plan projects and experiments
- able to meet deliverable and reporting deadlines
- excellent interpersonal skills, communication, and organisational skills
- headington, Oxfordshire: reliably commute or plan to relocate before starting work
Salary in other companies in the position research scientist
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